|To achieve healthy weight loss, most experts recommend a combination of healthy eating patterns and regular physical exercise. Among the many possible solutions for treating obesity are formulations of weight loss products that work with some of the basic biochemical processes involved in fat metabolism.
Ma Huang, or ephedra, contains ephedrine, an alkaloid that stimulates the production of catecholamines such as norepinephrine. Norepinephrine or noradrenaline is presumed to start the thermogenic process by stimulating metabolism in fat cells via the neurocrine axis that involves beta-adrenergic receptors. This in turn results in lipolysis. Ma huang increases basal metabolic rate (BMR), and help body burn calories faster. Ephedra sinica, the primary species of ma huang, is used as a weight-loss aid in people because of its stimulant effect and as a decongestant because of its vasoconstrictive effect.
Standardized green tea extract (standardized for 20% polyphenols) (leaf) inhibits the enzyme that causes the breakdown of norepinephrine, thus causing an increase in metabolic rate. It has also been shown to increase the rate of brown fat metabolism. Green tea extract is effective in stimulating thermogenesis by relieving inhibition at different control points along the NA-cAMP axis. Epigallocatechin gallate from green tea polyphenols significantly reduced food intake, body weight, blood cholesterol and triglyceride, as well as growth of the prostate, uterus, and ovary.
Chromium polynicotinate has been shown to possess greater biological activity and is safer than other chromium supplements. Chromium picolinate helps insulin to metabolize fat, turns protein into muscle, and converts sugar into energy. It potentiates the effects of insulin and helps overcome insulin resistance in overweight people. Chromium also seems to stimulate thermogenesis, the burning of fat, without any physical exertion.
St. John's Wort is a herb of the hypericaceae family which contains the therapeutically active ingredient hypercin. St. John's Wort functions to reduce weight and also acts as an appetite suppressant, most likely by controlling serotonin levels.
Glucosamine also contributes to weight loss. The effect of insulin on lipogenesis, the formation of fatty acids in the body, is blocked by glucosamine, indicating that glucosamine plays a role as a messenger for this insulin effect. Insulin is secreted when there is high sugar content, insulin secretion allows for fat storage. Glucose triggers a rise in insulin. Insulin acts to lower blood glucose levels, regulating those levels through several actions, including lipogenesis (conversion of carbohydrate and protein into fat). High insulin levels trigger the hypothalamus to send hunger signals, which sets off a craving for carbohydrates; this leads one to eat more, which leads to more insulin. Excess carbohydrates are converted into glucose, and then stored as fat.
Growth hormone (GH) has been implicated in a number of metabolic effects. Administration of exogenous growth hormone by injection has been shown to accelerate body fat loss. Obese people have a blunted or suppressed HGH release. Insulin levels are elevated in obesity, and high insulin levels also suppress human growth hormone production.
5-hydroxytryptophan is an effective nutrient that promotes weight loss. 5-Hydroxytryptophan (5-HTP) is the intermediate metabolite of the essential amino acid L-tryptophan (LT) in the biosynthesis of serotonin. 5-HTP is used by the human body to make serotonin The component gives the feeling of satiation and a calming effect. 5-HTP administration causes a significant increase in the hormone leptin. Leptin plays an imporant role in the regulation of appetite and other physiological processes, and various factors can alter leptin secretion. 5-HTP administration results in significant increases in insulin, corticosterone, and prolactin levels, and all of these hormones can increase leptin levels.
Hydroxycitric acid (HCA), a rare organic acid, reduces appetite and helps prevent excess carbohydrates from being stored as body fat. Hydroxycitric acid is derived from the Malabar tamarind tropical fruit (Garcinia cambogia) native to India. HCA has been found to inhibit mitochondrial citrate lyase, leading to decreased acetyl coenzyme A production and decreased fatty acid synthesis.
Chitosan supplements are promoted as weight-loss agents that act by preventing the absorption of dietary fats from the intestines. Chitosan is a special fiber which is able to "soak up" or absorb anywhere from six to ten times its weight in fat and oils. chitosan is able to significantly bind with fat molecules and convert them into a form which the human body does not absorb. Like some plant fibers, chitosan is not digestible, therefore it has no caloric value.
In addition to above weight loss products, other weight loss supplements also contribute weight loss effects, they include bitter orange, guarana, caffeine, country mallow, ginseng, glucomannan, psyllium , l-carnitine, vitamin B5, licorice, conjugated linoleic acid, pyruvate, dandelion, cascara, DHEA, and laminaria.