Vitamin supplements guide   Vitamins & health supplements guide

 
Vitamin E (tocopherol) review
Basics: fat-soluble antioxidant, acts as a co-enzyme in cellular membranes and serves as a scavenger for free radicals.
Benefits: vitamin E maintains the integrity of the body's intracellular membrane, helps protect against heart disease and the development of cancers by enhancing immune function.
Dosage: 10 mg/day for the adult man, 8 mg/day for the adult woman, and 3 mg/day for the infant.
Sources: vegetable oils and products made from these oils, wheat germ, nuts and green leafy vegetables.
Deficiency: vitamin E deficiency affects the central nervous system and may result in progressive neuromuscular disease.
Overdose: vitamin E overdose may interfere with the body's ability to clot blood, posing a risk to people taking blood thinners.
 
Perfect E by Vitabase
When only the best will do, Perfect E is the most complete and highest quality Vitamin E product available. Perfect E contains all the vitamin E compounds including extra gamma tocopherols and palm tocotrienols. Perfect E by Vitabase is manuafactured according to the highest pharmaceutical standards and uses only the best quality raw ingredients. Click here for more information.
 

Vitamin E succinate (alpha-tocopheryl succinate)


Vitamin E succinate (VES) is a derivative of the fat-soluble vitamin d-alpha-tocopherol or dl-alpha-tocopherol. The general term vitamin E refers to eight naturally occurring and synthetic tocopherols and tocotrienols and their acetate and succinate derivatives. D-Alpha-tocopherol succinate is the succinate ester of natural-source d-alpha-tocopherol. D-Alpha-tocopherol succinate is obtained by the vacuum steam distillation and succinylation of edible vegetable oil. Dl-Alpha-tocopheryl succinate is an all-synthetic form of alpha-tocopherol. It is produced by coupling racemic isophytol with trimethylhydroquinone to form dl-tocopherol.

Although the naturally occurring forms of vitamin E have lipid-soluble antioxidant properties that protect cell membranes against damage by free radicals, the acetate and succinate derivatives that are esterified at the C-6 position of the chromanol ring do not have antioxidant properties unless the esterification is hydrolyzed and free tocopherol is regenerated. The succinate form is water-soluble and the acetate form is fat-soluble. Vitamin E Succinate takes vitamin E's antioxidant action a step further. Succinate feeds directly into the Krebs cycle, our major metabolic pathway for generating energy. This extra dimension from succinate significantly extends the protective properties of vitamin E.

Vitamin E succinate is may inhibit growth and induced apoptic cell death in estrogen-receptor-negative human breast cancer cell lines. Vitamin E succinate is a potent novel antineoplastic agent with high selectivity and cooperativity with tumor necrosis factor-related apoptosis-inducing ligand. Vitamin E succinate may be of clinical use in the treatment of aggressive human breast cancers, particularly those that are resistant to anti-estrogen therapy. Alpha-tocopheryl succinate can suppress the expression of prostate-specific antigen (PSA), a marker for the progression of prostate cancer. VES can also suppress androgen receptor (AR) expression by means of transcriptional and posttranscriptional modulation.

Vitamin E succinate enhances the immune response and induces cellular differentiation and/or growth inhibition. Patent Inhibitor of neuroblastoma. cells, murine melanoma cells, avian lymphoid cells, human HL-60 promyelocytic leukemia cells, and several human breast carcinoma cell lines. VES has been shown to modulate adenylate cyclase and cAMP-dependent protein, inhibit protein kinase C activity, bind to cellular vitamin E binding protein, suppress c-myc and c-H-ras oncogene expression, and regulate TGFb protein production.